Guanfacine for ADHD

Guanfacine is a non-stimulant medicine (an alpha-2A adrenergic agonist). It acts on receptors in the prefrontal cortex involved in attention and impulse control. In the UK it is licensed for children and young people aged 6–17; use in adults is off-label and a specialist decision.

NICE NG87 sets out the order in which ADHD medicines are usually considered for children, young people and adults, and recommends that treatment is started by a specialist and reviewed regularly. Your prescriber will explain why a particular medicine is suggested for you.

Titration means starting at a low dose and adjusting it step by step, usually every one to two weeks, until the benefit outweighs any side effects. At ADHD Path each titration review checks symptoms, side effects, blood pressure, pulse and weight before any change.

This page is general information, not advice about your own treatment. Medicines are only considered after a diagnosis, when clinically appropriate, and are prescribed and adjusted by a qualified prescriber during titration with regular monitoring of blood pressure, pulse, weight, sleep and mood. Never start, stop or change a dose without speaking to your prescriber.

Shared care with your GP is subject to individual GP practice agreement and cannot be guaranteed.